Abstract - Drew Hall

As the global demographic ages, there has been a surge in neurological disorders worldwide. According to the WHO, more than 50 million people suffer from epilepsy and dementia continues to grow at the rate of 7.7 million new cases annually. It is thus imperative that low-cost, minimally-invasive neural signal monitoring systems are developed to record neural interactions and identify signs of synaptic dysregulation. Though a majority of current brain monitoring devices use microelectrode (ME) arrays on the surface or the inner-cortical regions, these modalities suffer from glial scar tissue formation around the electrodes leading to attenuation of the signal over time, limiting their lifetime. One possible solution is to measure the magnetic field around a neuron as opposed to the ionic current. Historically, various magnetic sensors have been used to monitor neural activity; however, despite their exquisite sensitivity, they must be operated at 4.2 Kelvin. To overcome the requirement for low-temperature operation, we propose using a magnetoresistive (MR) nanosensor capable of detecting low-magnetic fields at room temperature without loss of spatio-temporal information. An array of these nanosensors would provide a non-contact method for determining neural interactions while remaining naturally immune to changes in the underlying structure due to scar tissue.

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Principal Investigator Institution Title Abstract
Andersen, Richard California Institute of Technology Engineering Artificial Sensation View
Andrews, Anne University of California, Los Angeles Nanoscale Neurotransmitter Sensors View
Bloodgood, Brenda University of California San Diego A novel toolkit for visualizing and manipulating activity-induced transcription in living brain. View
Chaumeil, Myriam University of California, San Francisco In vivo metabolic imaging of neuroinflammation using hyperpolarized 13C View
Cleary, Michael University of California, Merced Capturing physiological maps of neural gene expression View
Cohen, Bruce University of California, Lawrence Berkeley National Laboratory Nano-optogenetic control of neuronal firing with targeted nanocrystals View
Dai, Hongjie Stanford University  Deep brain imaging of single neurons in the second near-infrared optical window View
Hall, Drew University of California, San Diego Magnetic Monitoring of Neural Activity using Magnetoresistive Nanosensors View
Krubitzer, Leah University of California, Davis An integrated system to monitor, image, and regulate neural activity View
Kubby, Joel University of California, Santa Cruz Three-Photon Microscopy with Adaptive Optics for Deep Tissue Brain Activity Imaging View
Melosh, Nicholas Stanford University Parallel Solid State Intracellular Patch-Clamping with Biomimetic Probes View
Park, B. Hyle University of California, Riverside  Label-free 4D optical detection of neural activity View
Portera-Cailliau, Carlos University of California, Los Angeles High-speed interrogation of network activity with frequency domain multiplexing View
Shanechi, Maryam University of Southern California Control-Theoretic Neuroprosthetic Design Using Electrocorticography Signals View
Smith, Will University of California, Santa Barbara Whole brain imaging in a primative chordate View
Wood, Marcelo University of California, Irvine Epigenetic PET tracer for cross-species investigation of age-related memory dysfunction View