Abstract - Leah Krubitzer

Our goal is to fabricate an integrated system to monitor, image, and regulate neural activity using an implantable, portable microfluidic device that through rapid cooling, produces reversible virtual “lesions” to the neocortex and regions of brain affected by disease. This device, termed the “Cooling Chip” abolishes neural activity while simultaneously monitoring neural activity, vascular shunting and local temperature without inducing any permanent damage to the brain. The technologies to be integrated in the final device have been utilized in animal models and humans by members of our team. These include the cooling chip itself; flexible, multichannel electrode arrays for recording neural activity; molecular and temperature sensing microsystems; and non-­‐invasive optical and infrared imaging. Our multidisciplinary team includes bioengineers, neuroscientists, and clinicians who will assimilate these technologies and translate them for use in numerous clinical applications including but not limited to: {i} Localization and reversible ‘ablation’ of epileptogenic foci; {ii} ”Reversible ablative mapping” of neural tissue prior to neurosurgical resection following brain injury or tumor removal; {ii} Circuit “retraining” for abnormalities ranging from cortically mediated phantom limb pain to PTSD. Given our combined expertise, in a short period of time this system can be translated from animal models to human trials.

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Principal Investigator Institution Title Abstract
Andersen, Richard California Institute of Technology Engineering Artificial Sensation View
Andrews, Anne University of California, Los Angeles Nanoscale Neurotransmitter Sensors View
Bloodgood, Brenda University of California San Diego A novel toolkit for visualizing and manipulating activity-induced transcription in living brain. View
Chaumeil, Myriam University of California, San Francisco In vivo metabolic imaging of neuroinflammation using hyperpolarized 13C View
Cleary, Michael University of California, Merced Capturing physiological maps of neural gene expression View
Cohen, Bruce University of California, Lawrence Berkeley National Laboratory Nano-optogenetic control of neuronal firing with targeted nanocrystals View
Dai, Hongjie Stanford University  Deep brain imaging of single neurons in the second near-infrared optical window View
Hall, Drew University of California, San Diego Magnetic Monitoring of Neural Activity using Magnetoresistive Nanosensors View
Krubitzer, Leah University of California, Davis An integrated system to monitor, image, and regulate neural activity View
Kubby, Joel University of California, Santa Cruz Three-Photon Microscopy with Adaptive Optics for Deep Tissue Brain Activity Imaging View
Melosh, Nicholas Stanford University Parallel Solid State Intracellular Patch-Clamping with Biomimetic Probes View
Park, B. Hyle University of California, Riverside  Label-free 4D optical detection of neural activity View
Portera-Cailliau, Carlos University of California, Los Angeles High-speed interrogation of network activity with frequency domain multiplexing View
Shanechi, Maryam University of Southern California Control-Theoretic Neuroprosthetic Design Using Electrocorticography Signals View
Smith, Will University of California, Santa Barbara Whole brain imaging in a primative chordate View
Wood, Marcelo University of California, Irvine Epigenetic PET tracer for cross-species investigation of age-related memory dysfunction View