Abstract - Myriam Chaumeil

Hyperpolarized (HP) 13C MR Spectroscopic Imaging (MRSI) is a non-ionizing, nonradioactive “real-time” imaging method that can be used safely in longitudinal studies. This technique has recently enabled the in vivo assessment of previously unexplored metabolic reactions with unprecedented temporal resolution. Over the last few years, this powerful technique has been used for cancer research, preclinically and in clinical trials, allowing for improved diagnosis, evaluation of tumor grade and assessment of therapy outcome. In this project, we propose to expand, to our knowledge for the first time, the use of HP 13C MRSI to the study of neuroinflammation in vivo. This technique will help identify new biomarkers specific of macrophages activation and polarization status that could dramatically improve our understanding of several brain diseases. Whereas this proposal focuses on Traumatic Brain Injury and Multiple Sclerosis at first, the methods developed in this project are applicable to every cerebral disease presenting an inflammatory component. Upon clinical translation, the neuroimaging methods developed in this project could have a major impact on clinical practice. They could improve diagnosis and monitoring of response to innovative therapeutic approaches, which would help refine therapeutic regimens and, ultimately, lead to better clinical outcome and patient quality of life.

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AWARDS

Principal Investigator Institution Title Abstract
Andersen, Richard California Institute of Technology Engineering Artificial Sensation View
Andrews, Anne University of California, Los Angeles Nanoscale Neurotransmitter Sensors View
Bloodgood, Brenda University of California San Diego A novel toolkit for visualizing and manipulating activity-induced transcription in living brain. View
Chaumeil, Myriam University of California, San Francisco In vivo metabolic imaging of neuroinflammation using hyperpolarized 13C View
Cleary, Michael University of California, Merced Capturing physiological maps of neural gene expression View
Cohen, Bruce University of California, Lawrence Berkeley National Laboratory Nano-optogenetic control of neuronal firing with targeted nanocrystals View
Dai, Hongjie Stanford University  Deep brain imaging of single neurons in the second near-infrared optical window View
Hall, Drew University of California, San Diego Magnetic Monitoring of Neural Activity using Magnetoresistive Nanosensors View
Krubitzer, Leah University of California, Davis An integrated system to monitor, image, and regulate neural activity View
Kubby, Joel University of California, Santa Cruz Three-Photon Microscopy with Adaptive Optics for Deep Tissue Brain Activity Imaging View
Melosh, Nicholas Stanford University Parallel Solid State Intracellular Patch-Clamping with Biomimetic Probes View
Park, B. Hyle University of California, Riverside  Label-free 4D optical detection of neural activity View
Portera-Cailliau, Carlos University of California, Los Angeles High-speed interrogation of network activity with frequency domain multiplexing View
Shanechi, Maryam University of Southern California Control-Theoretic Neuroprosthetic Design Using Electrocorticography Signals View
Smith, Will University of California, Santa Barbara Whole brain imaging in a primative chordate View
Wood, Marcelo University of California, Irvine Epigenetic PET tracer for cross-species investigation of age-related memory dysfunction View